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KMID : 0380020040190060437
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Korean Journal of Biotechnology and Bioengineering
2004 Volume.19 No. 6 p.437 ~ p.440
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Inhibitory Effect of Gardenia Fruit Extracts on Tyrosinase Activity and Melanogenesis
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Kwak Jung-Hoon
Kim Yong-Hae
Chang Hae-Ryong
Park Chul-Woo
Han Young-Hwan
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Abstract
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To determine the inhibition of tyrosinase activity and melanogenesis, gardenia fruit was extracted initially with ethanol (w/v), The ethanol extract was fractionated subsequently with hexane, chloroform and ethyl acetate in that order. The inhibitory effect of the ethanol extract on tyrosinase activity was higher than water extract. When 10 mg/mL of ethyl acetate fraction was applied, the inhibition ratio of tyrosinase activity was much higher () than that of arbutin. The inhibition of melanogenesis using B16F10 melanoma cell, the ethanol extract also showed higher inhibitory effect than water extract. The highest inhibitory activity of melanogenesis was also shown in ethyl acetate fraction ( at the cone. of ). These results suggests that gardenia extracts might be used to be a potential agents for whitening
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KEYWORD
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Gardenia jasminoides, inhibition, melanogenesis, tyrosinase
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